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mitochondrial O2 generation, indicating that mitochondrial ROS generation does occur downstream of EGFRactivation. Because F actin is demonstrated to regulate mitochondrial ROS production34,35 and topotentiate EGFR dimerization by clustering of EGFRs,36 we hypothesized that F actin might supply a l
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tocols adhered firmly to recommendations for the humane treatment of animals,and were accepted by the Institutional Animal Care and Use Committee of the University of Maryland. Experimentswere completed using adult female Wistar rats. For survival surgery, animals were fastedover night, anaestheti
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